Catenated Substrates

All our catenated DNA substrates are available separately and have been prepared to a high standard for accurate quantification of results. They are guaranteed for use with all our topoisomerase decatenation assay kits, buffers and enzymes.

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Kinetoplast catenated DNA (kDNA) is purified from Crithidia fasciculata using the method described in Shapiro (Shapiro et al., 1999)⁴ and is supplied at a concentration of 100 ng/µl in 10 mM Tris-HCl (pH8.0), 1 mM EDTA. kDNA is an excellent substrate for use in topo II or topo IV decatenation assays and results can be obtained more quickly than those from relaxation assays because the decatenated mini circles can easily be resolved from the non-decatenated material which remains in the wells of the gel. Store at 4°C.

Technical Documents

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Select a document...kDNA Data SheetkDNA MSDSkDNA lot#270217 Certificate of AnalysiskDNA lot 131217 Certicate of AnalysiskDNA Certificate of Analysis Lot#080618kDNA Certificate of Analysis Lot#290318View

Cat No.	Product	Price	Quantity
K2001	kDNA20 µg	£120
K1002	kDNA100 µg	£440
K2003	kDNA200 µg	£676
K4004	kDNA400 µg	£1,020

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Inspiralis

Inspiralis在提供高质量拓扑异构酶，连接酶和解旋酶方面享誉全球，包括检测试剂盒，底物和筛选服务。

We are located in laboratories adjacent to the academic research centres of the John Innes Centre and the University of East Anglia on the Norwich Research Park. We maintain close links with the academic research group of Professor Maxwell, helping us to remain at the forefront of the topoisomerase field. The experience of our staff and the connections with the academic group allow us to provide a high level of support to ensure that researchers are able to get the best results using our products. The same scientists who produce our enzymes and substrates also provide the technical support.

Our aim is to provide pharmaceutical companies, and others involved in drug development, with the necessary tools to develop and screen novel anti-infective and anti-cancer compounds. In order to achieve this we will continue to expand the range of topoisomerase products and screening services we offer.

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