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inspiralis/M. tuberculosis Gyrase/500 U of M. tuberculosis gyrase and 250 ug of relaxed DNA/MTS002

inspiralis/M. tuberculosis Gyrase/500 U of M. tuberculosis gyrase and 250 ug of relaxed DNA/MTS002
  • inspiralis/M. tuberculosis Gyrase/500 U of M. tuberculosis gyrase and 250 ug of relaxed DNA/MTS002
商品介绍

M. tuberculosis Gyrase

Click on the product headings below to view details and order online.

M. tuberculosis Gyrase (HIS)

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Mycobacterium tuberculosis gyrase is a bacterial type II topoisomerase which can introduce negative supercoils into DNA. It is a target antibacterial drugs and can be used for screening potential novel antibacterial compounds. It is prepared by overexpressing the subunits with C-terminal polyhistidine tags in E. coli and then purified by affinity chromatography.

It is supplied as an A2B2 complex in Dilution Buffer. Store at -80 °C.

All enzyme is supplied with 5X concentrated Assay Buffer and Dilution Buffer which are also available separately. 1 U of gyrase will supercoil 0.5 µg relaxed pBR322 DNA in 30 minutes at 37 °C.

See technical documents below for more detailed information and lot specific activities.

Technical Documents

Cat No.ProductPriceQuantity
MTG001M. tuberculosis Gyrase (HIS)100 U£105
MTG002M. tuberculosis Gyrase (HIS)500 U£325
Custom Quote

M. tuberculosis Gyrase (HIS) Supercoiling Assay Kits

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Kits are available containing everything required to perform supercoiling reactions and to test inhibitors. They contain M. tuberculosis gyrase, relaxed DNA substrate and the Assay and Dilution buffers. 

Technical Documents

Cat No.ProductPriceQuantity
MTS001M. tuberculosis Gyrase (HIS) Supercoiling Kit 1100 U of M. tuberculosis gyrase and 50 ug of relaxed DNA£172
MTS002M. tuberculosis Gyrase (HIS) Supercoiling Kit 2500 U of M. tuberculosis gyrase and 250 ug of relaxed DNA£607
Custom Quote

M. tuberculosis Gyrase (HIS) Decatenation Assay Kits

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These contain the M. tuberculosis gyrase and the kDNA substrate in addition to the Assay and Dilution buffers for decatenation reactions. 1 U of M. tuberculosis gyrase will decatenate 200 ng of kDNA when incubated in 1X Assay buffer in a total reaction volume of 30 µl at 37°C for 30 minutes. 

Technical Documents

Cat No.ProductPriceQuantity
MTD001M. tuberculosis Gyrase (HIS) Decatenation Assay Kit 1100 U of M. tuberculosis gyrase and 20 ug of kDNA£172
MTD002M. tuberculosis Gyrase (HIS) Decatenation Assay Kit 2500 U of M. tuberculosis gyrase and 100 ug of kDNA£607
Custom Quote

M. tuberculosis Gyrase Assay Kits for Cell Extracts

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These kits are designed for assaying cell extracts containing M. tuberculosis gyrase and partially purified fractions and contain relaxed DNA substrate, Assay buffer, Dilution buffer and control supercoiled DNA. 

Technical Documents

Cat No.ProductPriceQuantity
MTBE001M tuberculosis Gyrase Assay Kit 1 for Cell ExtractsFor 100 M. tuberculosis gyrase assays£136
MTBE002M tuberculosis Gyrase Assay Kit 2 for Cell ExtractsFor 500 M. tuberculosis gyrase assays£428
Custom Quote
品牌介绍

自1995年以来,我们一直为制药行业和学术界提供拓扑异构酶产品和服务,以协助抗感染和抗癌市场的研究。Inspiralis以前是John Innes Enterprises的公司,它是根据拓扑异构酶研究领域的全球领先者之一Tony Maxwell教授的研究建立的。

我们位于约翰·因内斯中心和东英吉利大学诺里奇研究园的学术研究中心附近的实验室。我们与麦克斯韦教授的学术研究小组保持着密切的联系,帮助我们保持在拓扑异构酶领域的最前沿。我们员工的经验以及与学术团体的联系使我们能够提供高水平的支持,以确保研究人员能够使用我们的产品获得最佳结果。生产我们的酶和底物的科学家也提供技术支持。

我们的目标是为制药公司和其他参与药物开发的公司提供开发和筛选新型抗感染和抗癌化合物的必要工具。为了实现这一目标,我们将继续扩大拓扑异构酶产品和筛选服务的范围。


inspiralis拓扑异构酶抑制剂的作用机理

拓扑异构酶抑制剂可能以多种方式起作用或在蛋白质的不同位点结合。例如,它们可以抑制酶的ATPase活性,充当裂解复合物稳定剂,嵌入DNA中或阻止DNA结合。我们可以进行不同的测定,这将有助于阐明抑制剂的作用方式。


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